Metabolic Disease Oncology Inflammation CNS Cardiovascular Partners
 
 
     
  Partnerships  
     
  To date, Plexxikon has signed major collaborations with Roche, Servier, Wyeth and Genentech.

Roche (2006) – Oncology
Focus: Co-development and commercialization of PLX4032, and other B-Rafv600E inhibitors
Status: Phase 1
Total deal potential: $706 million, plus royalties
Includes $46 million in upfront and guaranteed funding
Co-promote option in U.S.

Servier (2006) – Cardiovascular
Focus: Discovery of non-peptidic renin inhibitors
Status: Preclinical development
Total deal potential: $100 million, plus royalties

Wyeth (2004) – Type 2 Diabetes and other metabolic disease
Focus: Co-development of PPM-204 (PLX204), and other diabetes and obesity compounds
Status: Phase 2b
Total deal potential: $402 million, plus royalties
Includes $22 million upfront and guaranteed funding, and $50 million loan facility

Genentech (2003) – Oncology
Focus: Discovery of drug leads for single undisclosed kinase target
Status: Preclinical
Total deal potential: Includes upfront payment, multi-year research funding, milestones, plus royalties (terms undisclosed)
 
     
 
Metabolic Disease | Oncology | Inflammation | CNS | Cardiovascular | Partners
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