Clinical trials are research studies designed to evaluate a new drug or combination of drugs or a new use of a marketed drug. Plexxikon and its partners are currently conducting clinical trials in a number of disease indications and combination trials with other agents.

Additional information about our clinical trials is available at www.clinicaltrials.gov, which gives an overview of the clinical trials process and lists a central database of all clinical trials in the U.S.

For more information about clinical trials of vemurafenib:

In the U.S.:

Phone: 1-888-662-6728, Monday-Friday, 9am - 6pm (ET)

Email: genentechclinicaltrials@druginfo.com

Web: www.clinicaltrials.gov

Outside the U.S.:

Web: www.roche-trials.com

For more information about clinical trials of PLX3397 or PLX5622:

Phone: 1-510-647-4000, Monday-Friday, 9am - 5pm (PT)

Email: plexxikondrug@plexxikon.com

Web: www.clinicaltrials.gov